Urgent : de nouvelles variantes de Covid-19 se propagent dans le monde

By | January 14, 2021
Urgent de nouvelles variantes de Covid-19 se propagent dans le monde
Urgent de nouvelles variantes de Covid-19 se propagent dans le monde

La nouvelle variante du coronavirus continue de se propager dans le monde. Alors que plusieurs pays ont annoncé des cas confirmés de la variante britannique, les scientifiques du monde entier redoublent leurs efforts de recherche sur les variantes du « SRAS CoV-2 », lors d’un forum organisé mardi par l’Organisation mondiale de la santé (OMS).

Mercredi 13 janvier 2021

Depuis leur première détection le 14 décembre dernier, les « COV 202012/01 » ont été signalées à ce jour dans une cinquantaine de pays, territoires et zones dans cinq des six régions de l’OMS.

« En Angleterre, la variante a été détectée dans toutes les régions et presque toutes les autorités locales », souligne l’Agence sanitaire mondiale de l’ONU dans son dernier bulletin épidémiologique.

Depuis sa première notification le 18 décembre 2020, la variante « sud-africaine » du « 501Y.V2 » a été détectée dans 20 pays ou territoires dans quatre des six régions de l’OMS.

D’après les enquêtes préliminaires et en cours en Afrique du Sud, il est possible que cette variante soit plus transmissible que les variantes circulant en Afrique du Sud auparavant. De plus, bien que cette nouvelle variante ne semble pas provoquer de maladie plus grave, l’augmentation rapide du nombre de cas observée a mis « les systèmes de santé sous pression ».

Une variante venue du Brésil détectée au Japon

L’agence onusienne a également annoncé avoir été informée par le Japon de la découverte d’une nouvelle variante du coronavirus sur son territoire. « Le 9 janvier, le Japon a notifié à l’OMS une nouvelle variante du « SRAS CoV-2 » dans la lignée du « B.1.1.28 » (initialement signalée comme B.1.1.248) », précise l’OMS, relevant que cette variante a été détectée chez quatre voyageurs arrivés de l’Etat brésilien de l’Amazonas.

Cette variante présente douze mutations, dont une a déjà été repérée dans des variantes « hautement contagieuses au Royaume-Uni et en Afrique du Sud ». Selon l’OMS, les chercheurs brésiliens ont en outre signalé l’émergence d’une variante similaire, également porteuse d’une mutation « E484K », qui a probablement évolué « indépendamment de la variante détectée chez les voyageurs japonais ».

Mais pour l’agence onusienne, l’étendue géographique des variantes britannique et sud-africaine du coronavirus « est probablement sous-estimée », en raison de « la capacité de séquençage et des défis d’adaptation des systèmes de surveillance pour les détecter » dans certains pays.

« L’amélioration de la couverture géographique du séquençage est essentielle pour que le monde puisse avoir les yeux et les oreilles sur les changements du virus », a déclaré hier mardi lors d’une réunion virtuelle d’experts, la Dre Maria Van Kerkhove, Responsable technique de l’OMS pour la Covid-19.

Plus de 350.000 séquences partagées publiquement

« L’étendue et l’importance de ces nouvelles variantes pour la santé publique doivent être étudiées plus », a ajouté l’OMS, rappelant que le « séquençage génomique a été essentiel pour identifier ces nouvelles variantes ». A ce jour, l’OMS note qu’« un nombre étonnant de 350.000 séquences ont été partagées publiquement, mais la plupart proviennent d’une poignée de pays seulement ».

A noter qu’une réunion, en visioconférence, a rassemblé hier mardi plus de 1.750 experts de 124 pays. « La science et la recherche ont joué un rôle essentiel dans la réponse à la pandémie depuis le premier jour et continueront d’être au cœur de tout ce que fait l’OMS », a déclaré lors de son discours de bienvenue, le Dr Tedros Adhanom Ghebreyesus, Directeur général de l’OMS.

La consultation s’est articulée autour de six thématiques couvrant l’épidémiologie et la modélisation mathématique, la biologie évolutive, les modèles animaux, les essais et les diagnostics, la gestion clinique ainsi que les thérapies et les vaccins.

Il est bien connu que les virus changent constamment par mutation, et l’émergence de nouvelles variantes est donc un phénomène attendu. De nombreuses mutations n’ont pas d’impact sur le virus lui-même, tandis que certaines pourraient être « préjudiciables au virus et que peu pourraient lui être bénéfiques ».

D’une manière générale, l’OMS estime qu’il est « normal que les virus mutent, mais plus le virus du « SRAS-CoV-2 » se répand, plus il a de chances de changer ». Et des niveaux élevés de transmission signifient qu’il faudra s’attendre à « l’apparition de nouvelles variantes ».

Pour un « séquençage systématique » des voyageurs entrants et échantillons communautaires

« Parmi les variantes importantes signalées jusqu’à présent, certaines sont associées à une augmentation de la transmissibilité, mais pas de la gravité de la maladie », précise toutefois l’OMS, ajoutant que des recherches sont en cours pour déterminer si ces changements ont une incidence sur l’évolution de la maladie.

A ce sujet, des recherches sont en cours pour déterminer l’impact des nouvelles variantes sur la transmission, la gravité de la maladie ainsi que tout impact potentiel sur les vaccins, les thérapies et les diagnostics. Pour l’OMS, ces efforts nécessiteront une coordination de la recherche entre l’OMS, ses partenaires et des groupes de scientifiques internationaux, notamment le Groupe de travail de l’OMS sur l’évolution des virus.

Plus largement, un « séquençage systématique » devrait être envisagé sur certains voyageurs entrants, ainsi que des échantillons communautaires pour vérifier l’existence et l’étendue de la transmission locale.

« Notre objectif collectif est de prendre de l’avance et de disposer d’un mécanisme mondial permettant d’identifier et d’étudier rapidement les variantes préoccupantes et de comprendre leurs implications pour les efforts de lutte contre la maladie », a déclaré la Dre Ana Maria Henao Restrepo de l’Initiative OMS pour la recherche sur les vaccins.

Dans ce combat contre le nouveau coronavirus, l’OMS soutient que l’amélioration de la surveillance et des capacités des laboratoires à surveiller les « souches préoccupantes » doit s’accompagner d’un partage rapide des échantillons du virus et de sérum par le biais de mécanismes convenus à l’échelle mondiale.

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